- September 25, 0303 “On a voyage preaching the gospel, Saint Fermin of Pamplona is beheaded in Amiens, France.”

- September 25, 1066 The Battle of Stamford Bridge marks the end of the Anglo-Saxon era.
- September 25, 1396 Ottoman Emperor Bayezid I defeats a Christian army at the Battle of Nicopolis.
- September 25, 1492 “Crewman on the Pinta sights “”land””-a few weeks early”
- September 25, 1493 Columbus sails on 2nd voyage to America
- September 25, 1513 Spanish explorer Vasco Nez de Balboa reached what would be known as the Pacific Ocean.
- September 25, 1513 Vasco Nu¤ez de Balboa is the first European to see the Pacific Ocean
- September 25, 1555 The Peace of Augsburg is signed in Augsburg by Charles V and the princes of the Schmalkaldic League.
- September 25, 1639 First printing press in America
- September 25, 1690 “””Publick Occurrences Both Foreign and Domestick””, the first newspaper to appear in the Americas, is published for the first and only time.”
- September 25, 1690 “Publick Occurrences, first US (Boston) newspaper, publish first & last ed”
- September 25, 1789 Congress proposes Bill of Rights (10 of 12 will ratify)
- September 25, 1804 “12th amendment to the US constitution, regulating judicial power”
- September 25, 1804 The Teton Sioux (a subdivision of the Lakota) demand one of the boats from the Lewis and Clark Expedition as a toll for moving further upriver.
- September 25, 1846 U.S. forces led by Zachary Taylor captured the Mexican city of Monterrey.
- September 25, 1861 Secretary of US Navy authorizes enlistment of slaves
- September 25, 1868 The Imperial Russian steam frigate Alexander Neuski shipwrecks off Jutland while carrying Grand Duke Alexei of Russia.
- September 25, 1890 Congress establishes Yosemite National Park (Calif)
- September 25, 1906 “In the presence of the king and before a great crowd, Leonardo Torres Quevedo successfully demonstrates the invention of the Telekino in the port of Bilbao, guiding a boat from the shore, in what is considered the birth of the Remote control.”
- September 25, 1911 “Ground is broken for Fenway Park in Boston, Massachusetts.”
- September 25, 1912 “Columbia University Graduate School of Journalism is founded in New York, New York.”
- September 25, 1915 The Second Battle of Champagne begins.
- September 25, 1919 Pres Wilson becomes seriously ill and collapses after a speech
- September 25, 1926 “Henry Ford announces the 8 hour, 5-day work week”
- September 25, 1926 International slavery convention signed by 20 states
- September 25, 1929 Jimmy Doolittle performs the first blind flight from Mitchel Field proving that full Instrument Flying from take off to landing is possible.
- September 25, 1934 Lou Gehrig plays in his 1500th consecutive game
- September 25, 1934 Rainbow (US) beats Endeavour (England) in 16th America’s Cup
- September 25, 1939 “Versailles Peace Treaty forgot to include Andorra, so Andorra and Germany finally sign an official treaty ending WW I”
- September 25, 1940 Cdn. Armed Merchanman Prince Rupert captures the German ship Wesser off Mexico
- September 25, 1942 “2,000 Jews are deported to Treblinka after a Jewish council chairman, Abraham Gamzu, refuses Gestapo demands to deliver Jews.”
- September 25, 1942 Japanese withdrawal begins along Owen Stanley Trail starts
- September 25, 1944 “Surviving elements of the British 1st Airborne Division withdraw from Arnhem in the Netherlands, thus ending Operation Market Garden.”
- September 25, 1955 The Royal Jordanian Air Force is founded.
- September 25, 1957 300 US Army troops guard 9 black kids return to Central HS in Ark
- September 25, 1957 “Central High School in Little Rock, Arkansas, is integrated through the use of United States Army troops.”
- September 25, 1957 Soviet 7 year plan (1959-1965) announced
- September 25, 1959 “Solomon Bandaranaike, prime minister of Sri Lanka is mortally wounded by a Buddhist monk, Talduwe Somarama, and dies the next day.”
- September 25, 1962 A black church is destroyed by fire in Macon Georgia
- September 25, 1962 Weatherly (US) beats Gretel (Aust) in 19th running of America’s Cup